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Colorectal Cancer Screening Guidelines Include New Alternative to Colonoscopy

Rubenhair Latvia
2 min read
03.06.2026
Colorectal Cancer Screening Guidelines Include New Alternative to Colonoscopy

on PinterestNew colorectal cancer screening guidelines include blood-based and at-home stool tests.

on PinterestNew colorectal cancer screening guidelines include blood-based and at-home stool tests. Jacob Wackerhausen/Getty Images

  • The American Cancer Society (ACS) has updated its colorectal cancer screening recommendations to include new blood and stool-based tests.
  • The new guidelines reflect the availability of new disease detection technology and the need to expand access to screenings.
  • The ACS states that screenings are vital as colorectal cancer rates continue to rise in adults under 50.

The American Cancer Society (ACS) has updated its guidelines for colorectal cancer screening to include new blood-based and at-home stool tests.

The new blood test screens for tumor DNA, while the at-home tests look for DNA, RNA, and blood markers in stool samples.

The updated guidelines still retain ACS recommendations for starting colorectal cancer screening at age 45 and having colonoscopies done every 10 years for people who are at average risk of colorectal cancer.

The organization published its new recommendations on May 27 in CA: A Cancer Journal for Clinicians.

ACS officials said the new guidelines reflect advances in disease detection and a shift in public health strategy to expand screening options and lower barriers to access.

“We need to increase our emphasis on colorectal cancer as a highly preventable disease as much as a treatable one,” said Robert Smith, PhD, senior vice president for early cancer detection science at the American Cancer Society and senior author of the report, in a news release.

“By offering more screening tools in our guideline update, more eligible adults will be able to participate in lifesaving colorectal cancer testing, helping to close the screening gap and catch more cancers at an earlier, treatable stage,” Smith continued.

Experts not involved in the report told Healthline that providing more alternatives to colonoscopy is a good course of action.

“I definitely think that presenting more options is better,” said Babak Firoozi, MD, a gastroenterologist at MemorialCare Orange Coast Medical Center in California. “It helps to have these available. It’s important to increase the number of people who are being screened anyway we can,” he said.

Anton Bilchik, MD, a surgical oncologist, chief of medicine, and the director of the Gastrointestinal and Hepatobiliary Program at Providence Saint John’s Cancer Institute in California, agreed. “There are so many people who don’t have access or don’t want to do a colonoscopy screening,” he said. “This really will increase the number of people willing to get screened.”

New tests available for colorectal cancer screening

Two at-home stool sample tests are mentioned in the ACS report.

The first is an updated version of the DNA test sold under the brand name Cologuard. This screening analyzes stool samples for specific DNA markers and hemoglobin.

The second is a new multi-target test sold under the brand name ColoSense. This test analyzes stool samples for specific RNA markers and hemoglobin.

According to a news release, both tests “demonstrate high sensitivity for colorectal cancer and moderate sensitivity for advanced precancerous lesions.

They recommend these tests be conducted on people over the age of 45 with average risk every 3 years.

The report also lists one blood-based test. It’s sold under the brand

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